Joe, thanks for the response. I do not have any iRules in place. I simply said from what I see from other iRules viewed they seem to complicated for what I need. May be this example will help. If I go to www.domain.com (which passes through the BigIP VIP address) everything is fine. If I go to http://www.domain.com/neededupdate/do.php I get directory not found.
Now going to each webserver in the pool http://IP-of-Webserver/neededupdate/do.php works fine.
It seems as if the going through the BigIP introduces some sort of issue. Any ideas?