Forum Discussion
A few things:
You mention Forwarding IP, and Layer 2 Virtual Server. These are 2 different types of virtual servers, you should be using a Forwarding IP Virtual Server, not a Layer 2.
Do you have a route on the Nexus switch pointing 10.121.1.0/24 to the BIG-IP on the 10.121.16.0 network? You want to make sure that the traffic is flowing through the BIG-IP in both directions.
The Forwarding IP virtual server should be enabled on All VLANs, or at least both of the VLANs that traffic is flowing in and out of, in order to allow access to the servers and to allow the servers access out of their VLAN.
I suspect the issue is the second, and traffic is flowing around the BIG-IP as it arrives to the server, the server is sending the SYN ACK to the BIG-IP and the BIG-IP is dropping it.
If there are other servers on this VLAN and you cannot route all traffic through the BIG-IP, then you will have to enable Loose Initiate and Loose Close on the FastL4 profile that you assign to the Forwarding IP VS.