Thank you for your information. I have finished the patch process for the BigIP VE 10.2.1 follow the link you provided. However I still want to paste the detailed steps here for your confirmation.
1. Import the latest hotfix iso image "Hotfix-BIGIP-10.2.1-511.0-HF3.iso" and base OS iso image "BIGIP-10.2.1.297.0.iso" in to the "shared/images" directory of BigIP VE.
2. Go to the UI management portal. Select the hotfix just imported and set the attribute "Install Volume" as "HD1.2". Then click the button "Install".
NOTE:
1. The volume "HD1.1" is installed with the BigIP 10.2.1 base OS by default when the vm is deployed into the ESX hypervisor.
2. The volume "HD1.2" has no any base OS installed on.
One Question:
Do i need firstly install the base OS iso file on the partition "HD1.2" and then patch the hotfix on that partition?
3. After the patch process finished, set the system "Boot Partition" attribute to "HD1.2", which was "HD1.1" before. And then click the "Activate" button.
NOTE: After that, the OS is rebooted and the the "HD1.2" partition becomes the active boot partition.
4. After Step 4, the BigIP VE 10.2.1 is patched with the latest hotfix and ready for use.