Having an issue where we cannot make outbound connections from the servers behind an F5 BIG-IP LTM. The setup is as follows:
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| VLAN: 224 (10.22.4.5 / 10.22.4.4
...
do you have snat automap or a snatpool assigned to your wildcard virtual server? If not, your firewall is probably dropping the traffic as the source of the traffic will be the web server 10.22.2.* address.